Table 4.
Changes in Hemodynamics With Arterial Infusion of Tyramine and Phenylephrine—Protocol 2
| Leg | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TER+PLA | TER+PROB | TER+PLA | TER+PROB | |||||||||
| Variable | TYR 0.15 | TYR 0.3 | TYR 1.0 | TYR 0.15 | TYR 0.3 | TYR 1.0 | PE 0.75 | PE 1.5 | PE 3.0 | PE 0.75 | PE 1.5 | PE 3.0 |
| Blood flow, % | −29.1±2.3 | −55.2±3.1 | −76.1±2.9 | −22.3±2.7* | −41.5±3.0* | −74.3±7.1 | 7.9±6.4 | 19.4±9.1 | 21.4±9.4 | 6.1±5.8 | 28.6±9.4 | 46.5±18.0 |
| Mean arterial blood pressure, mm Hg | 1±0 | 0±1 | 5±1 | 1±1 | 1±1 | 5±1 | 0±1 | −1±1 | 2±1 | 0±1 | 0±1 | 2±1 |
| Vascular conductance, % | −30.0±2.4 | −55.5±3.3 | −77.5±2.9 | −23.2±1.9* | −42.5±2.2* | −76.4±5.9 | 8.1±7.2 | 21.0±10.7 | 18.5±10.4 | 6.4±6.2 | 27.8±11.3 | 42.7±16.4 |
| Heart rate, bpm | 1±0 | 1±0 | 5±1 | 1±1 | 0±1 | 2±2 | 1±1 | 0±1 | 3±1 | 0±1 | 1±1 | 2±1 |
| Venous norepinephrine, nmol L−1 | −1.4±1.6 | 0.8±2.0 | 5.0±2.5 | 0.4±1.9 | 0.8±1.5 | 8.0±2.8 | … | … | … | … | … | … |
Values are means±SE. n=5. TER+PLA indicates terazosin+placebo; and TER+PROB, terazosin+probenecid.
*
Significantly different from PLA (P<0.05).