TABLE 2.

Antidepressant response in children and adolescents with generalized, separation and social anxiety disorders over time and across treatment models.

	Summary Response			SSRI Response			SSNRI Response			High Dose SSRI Response			Low Dose SSRI Response
Time (week )	δ	95% Credible Interval	Significance (vs. baseline)	δ	95% Credible Interval	Significance (vs. baseline)	δ	95% Credible Interval	Significance (vs. baseline)	δ	95% Credible Interval	Significance (vs. baseline)	δ	95% Credible Interval	Significance (vs. baseline)
0	−0.002	−0.024, −0.020	p=0.698	−0.001	−0.011, 0.009	p=0.718	−0.004	−0.047, 0.040	p=0.714	0.02	−0.014, 0.017	p=0.729	−0.016	−0.183, 0.150	p=0.711
2	−0.054	−0.076, −0.032	p=0.005	−0.087	−0.096, −0.077	p<0.001	−0.042	−0.086, 0.000	p=0.021	−0.088	−0.103, −0.072	p=0.002	−0.087	−0.254, 0.080	p=0.149
4	−0.091	−0.113, −0.069	p=0.002	−0.148	−0.157, −0.138	p<0.001	−0.069	−0.113, −0.026	p=0.006	−0.151	−0.167, −0.136	p<0.001	−0.137	−0.304, 0.029	p=0.065
6	−0.120	−0.142, −0.097	p=0.001	−0.195	−0.204, −0.185	p<0.001	−0.091	−0.134, −0.047	p=0.003	−0.201	−0.216, −0.185	p<0.001	−0.176	−0.343, −0.009	p=0.051
8	−0.143	−0.165, −0.121	p=0.001	−0.234	−0.243, −0.224	p<0.001	−0.108	−0.152, −0.065	p=0.002	−0.241	−0.256, −0.225	p<0.001	−0.208	−0.374, −0.041	p=0.025
10	−0.163	−0.185, −0.141	p<0.001	−0.266	−0.276, −0.256	p<0.001	−0.122	−0.166, −0.079	p=0.002	−0.275	−0.290, −0.259	p<0.001	−0.235	−0.401, −0.068	p=0.023
12	−0.180	−0.202, −0.158	p<0.001	−0.294	−0.304, 0.284	p<0.001	−0.135	−0.179, −0.092	p<0.001	−0.304	−0.320, −0.289	p<0.001	−0.258	−0.425, −0.091	p=0.018

Note: Negative values reflect improvement. SSRI = selective serotonin reuptake inhibitor; SSNRI = selective serotonin norepinephrine reuptake inhibitor; δ = standardized medication-placebo difference.