Table 3.
Relative Abundance of Bile Acids in Sprague Dawley and PCK Rats as a Percentage of Total Bile Acid Concentrations in Each Matrix
| Matrix | Bile Acid Species | Sprague-Dawley (% of total) |
PCK (% of total) |
|---|---|---|---|
| Liver | CA species | 55.111 ± 10.543 | 44.845 ± 5.685 |
| CDCA species | 9.531 ± 3.947 | 5.802 ± 0.695* | |
| DCA species | 10.743 ± 4.258 | 5.433 ± 1.897* | |
| HDCA species | 1.392 ± 0.323 | 17.628 ± 3.433* | |
| LCA species | 1.788 ± 0.224 | 0.398 ± 0.160* | |
| MCA species | 19.829 ± 4.429 | 24.822 ± 7.839 | |
| UDCA species | 1.605 ± 0.571 | 1.071 ± 0.166 | |
| Bile | CA species | 64.959 ± 6.887 | 48.736 ± 4.633 |
| CDCA species | 11.399 ± 3.933 | 5.893 ± 1.102 | |
| DCA species | 6.387 ± 2.253 | 5.671 ± 1.100 | |
| HDCA species | 1.203 ± 0.054 | 17.167 ± 4.000 | |
| LCA species | 0.656 ± 0.131 | 0.262 ± 0.052 | |
| MCA species | 14.171 ± 4.470 | 21.234 ± 5.652 | |
| UDCA species | 1.225 ± 0.372 | 1.036 ± 0.039 | |
| Serum | CA species | 56.131 ± 13.481 | 35.281 ± 6.634 |
| CDCA species | 11.211 ± 9.440 | 3.297 ± 0.898* | |
| DCA species | 6.310 ± 0.740 | 5.178 ± 0.897 | |
| HDCA species | 1.397 ± 0.258 | 34.089 ± 6.913* | |
| LCA species | 0.470 ± 0.111 | 0.166 ± 0.040* | |
| MCA species | 22.905 ± 4.910 | 20.673 ± 4.204 | |
| UDCA species | 1.577 ± 0.538 | 1.317 ± 0.117 | |
| Urine | CA species | 57.001 ± 5.754 | 37.826 ± 2.860* |
| CDCA species | 2.696 ± 1.737 | 2.865 ± 1.477 | |
| DCA species | 2.149 ± 1.329 | 1.584 ± 0.342 | |
| HDCA species | 11.003 ± 8.165 | 20.814 ± 3.796 | |
| LCA species | 1.204 ± 0.675 | 0.621 ± 0.070 | |
| MCA species | 24.317 ± 10.581 | 35.433 ± 6.151 | |
| UDCA species | 1.630 ± 1.384 | 0.857 ± 0.203 |
Data are presented as mean ± standard deviation (n=4/cohort except n=3 in bile of Sprague-Dawley rats).
*
p < 0.05, Sprague-Dawley vs. PCK rats. See Table 1 for abbreviations of bile acids.