Table 3.
Partial correlations between the methylations of POMC, MC4R, and HNF4A and metabolic profiles adjusted for age, Unit: r (P)
| TG | TC | HDL-c | Insulin | Glucose | HOMA | |
|---|---|---|---|---|---|---|
| POMC | ||||||
| POMC–CpG1 | 0.03 (0.75) | − 0.04 (0.71) | − 0.20 (0.03)a | − 0.03 (0.73) | −0.03 (0.76) | − 0.05 (0.60) |
| POMC–CpG2 | 0.04 (0.70) | −0.09 (0.34) | −0.23 (0.01)a | − 0.03 (0.75) | −0.05 (0.61) | − 0.06 (0.54) |
| POMC–CpG3 | 0.06 (0.53) | −0.04 (0.71) | −0.19 (0.04)a | − 0.03 (0.77) | −0.02 (0.84) | − 0.05 (0.62) |
| POMC–CpG4 | 0.02 (0.87) | −0.05 (0.56) | −0.20 (0.03)a | − 0.06 (0.52) | −0.05 (0.58) | − 0.09 (0.35) |
| MC4R | ||||||
| MC4R–CpG1 | 0.14 (0.14) | −0.03 (0.78) | −0.15 (0.11) | 0.14 (0.14) | 0.03 (0.79) | 0.12 (0.18) |
| MC4R–CpG2 | 0.08 (0.41) | −0.03 (0.74) | −0.03 (0.72) | 0.18 (0.06) | −0.05 (0.58) | 0.12 (0.20) |
| MC4R–CpG3 | 0.06 (0.50) | −.0.06 (0.50) | −0.05 (0.61) | −0.14 (0.14) | 0.00 (1.00) | −0.13 (0.16) |
| HNF4A-P1 | ||||||
| HNF4A–CpG1 | 0.12 (0.21) | −0.003 (0.98) | 0.03 (0.72) | 0.14 (0.14) | 0.06 (0.51) | 0.12 (0.20) |
| HNF4A–CpG2 | 0.12 (0.20) | −0.13 (0.17) | −0.04 (0.65) | 0.07 (0.49) | 0.14 (0.14) | 0.11 (0.23) |
| HNF4A–CpG3 | −0.12 (0.19) | −0.19 (0.05) | − 0.17 (0.07) | −0.17 (0.08) | 0.01 (0.94) | −0.16 (0.09) |
| HNF4A–CpG4 | 0.02 (0.80) | −0.32 (0.001)a | − 0.20 (0.04)a | − 0.10 (0.30) | −0.01 (0.92) | − 0.09 (0.35) |
| HNF4A-P2 | ||||||
| HNF4A–CpG1 | 0.003 (0.98) | 0.00 (1.00) | 0.04 (0.69) | −0.15 (0.10) | −0.09 (0.32) | − 0.11 (0.24) |
| HNF4A–CpG3 | −0.04 (0.64) | 0.30 (0.001)a | 0.11 (0.25) | 0.04 (0.69) | −0.02 (0.86) | 0.06 (0.55) |
| HNF4A–CpG4 | 0.03 (0.77) | −0.07 (0.43)a | − 0.14 (0.14) | −0.05 (0.62) | − 0.05 (0.60) | −0.01 (0.88) |
aindicate statistically significant correlations
POMC proopiomelanocortin, MC4R melanocortin 4 receptor, HNF4A hepatocyte nuclear 4 alpha, P promoter region, TG triglyceride, TC total cholesterol, HDL–c high-density lipoprotein cholesterol