Table 4.
Associations between DNA methylation status at CpG sites and metabolic profiles adjusted for age, gender, and BMI
| TC | HDL–c | |||
|---|---|---|---|---|
| β (SE) | p | β (SE) | p | |
| POMC | ||||
| POMC–CpG1 | −0.15 (0.24)* | 0.52 | −0.20 (0.11)* | 0.08 |
| POMC–CpG2 | −0.32 (0.25)* | 0.20 | −0.23 (0.12)*,a | 0.048a |
| POMC–CpG3 | − 0.16 (0.24)* | 0.50 | − 0.18 (0.11)* | 0.12 |
| POMC–CpG4 | −0.23 (0.26)* | 0.39 | −0.20 (0.12)* | 0.10 |
| HNF4A–P1 | ||||
| HNF4A–CpG4 | −2.79 (0.76)*,a | 0.001† | −0.67 (0.37)* | 0.07 |
| HNF4A–P2 | ||||
| HNF4A–CpG3 | 5.70 (1.76)*,a | 0.002† | 1.14 (0.86) | 0.19 |
Results are presented as coefficients (β) and SE after adjusting for age, gender, and BMI
aindicate statistically significant associations. * indicates the hypomethylated