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. 2018 Mar 29;19:46. doi: 10.1186/s13059-018-1418-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Alternative TSSs and exons are significantly associated with known and novel poly(A) signals. a Bar charts show the number and relative proportion of PASs that are associated with canonical or non-canonical poly(A) signals for all PASs, PASs with significant coupling, and alternative exon- and/or TSS-linked PASs. b Bar charts represent the number and relative proportion of known and unknown poly(A) signals for TSS-linked, exon-linked, or TSS- and exon-linked PASs