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. Author manuscript; available in PMC: 2018 Apr 28.
Published in final edited form as: J Med Chem. 2017 Apr 12;60(8):3451–3471. doi: 10.1021/acs.jmedchem.7b00295

Scheme 6. Synthesis of Tetrazole Analoguea.

Scheme 6

aReagents and conditions: (a) SOCl2, benzene, 80 °C, then NH3; (b) TFAA, pyridine, THF; (c) NaOMe, MeOH, 75 °C; (d) Et3N·HCl, NaN3, 1:1 toluene:DMF, 160 °C, ion-exchange using Na+-Dowex resin.