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. Author manuscript; available in PMC: 2018 Apr 28.
Published in final edited form as: J Med Chem. 2017 Apr 12;60(8):3451–3471. doi: 10.1021/acs.jmedchem.7b00295

Table 4.

In Vitro Absorption of Bile Acids at 10 μM in a Caco-2 Cell Monolayer Bidirectional Permeability Assay

compd mean permeability A–B (10−6 cm/s) mean permeability B–A (10−6 cm/s)
20b 6.1 0.5
21b 0.1 2.1
37a 10.7 1.9
38a 0.4 0.4