Table 3. The incremental prognostic information of each marker was assessed by performing separate multivariable Cox regression analyses including each marker and the IGCCCG risk groupings.
|
Overall survival |
||
|---|---|---|
| HR (95% CI) | P-value | |
| IGCCCG risk groups (good/intermediate vs poor risk) | 0.142 (0.032–0.623) | 0.010 |
| Haemoglobin (g l−1) | 0.983 (0.958–1.007) | 0.17 |
| IGCCCG risk groups (good/intermediate vs poor risk) | 7.26 (2.03–26.0) | 0.002 |
| Leukocytes (103 per μl) | 1.27 (1.06–1.54) | 0.011 |
| IGCCCG risk groups (good/intermediate vs poor risk) | 0.180 (0.047–0.686) | 0.012 |
| Neutrophils (103 per μl) | 1.47 (1.09–1.98) | 0.011 |
| IGCCCG risk groups (good/intermediate vs poor risk) | 0.117 (0.017–0.810) | 0.030 |
| CRP (mg l−1) | 1.01 (1.00–1.02) | 0.062 |
| IGCCCG risk groups (good/intermediate vs poor risk) | 0.131–0.008–2.12) | 0.15 |
| Albumin (g l−1) | 0.981 (0.768–1.25) | 0.88 |
| IGCCCG risk groups (good/intermediate vs poor risk) | 0.130 (0.036–0.464) | 0.002 |
| NLRa | 84.5 (2.2–3193) | 0.017 |
| IGCCCG risk groups (good/intermediate vs poor risk) | 0.161 (0.042–0.615) | 0.008 |
| SIIa | 12.1 (1.17–126) | 0.037 |
Abbreviations: CI=confidence interval; CRP=C-reactive protein; HR=hazard ratio; IGCCCG=International Germ Cell Cancer Collaborative Group; NLR=neutrophils-to-lymphocytes ratio; SII=systemic immune-inflammation index.
a
After log10 transformation: the HR thus corresponds to a 10-fold increase of the variable, bold P-values indicate statistical significance.