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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: J Orthop Res. 2017 Nov 22;36(2):699–710. doi: 10.1002/jor.23779

Figure 5. Decreased inflammatory protease activity in unloaded injured limbs.

Figure 5

(A) Representative FRI images of ground control (GC) and hindlimb unloaded (HLU) limbs at days 3 and 7 after fracture or ACL rupture. Pink circles represent regions of interest for analysis. (B-C) Total radiant efficiency for injured and contralateral limbs for each injury type after 3 and 7 days of either normal ambulation or hindlimb unloading. HLU reduced inflammation and protease activity in injured limbs, particularly in ACL ruptured mice. * indicates total radiant efficiency of injured limbs is significantly greater than that of paired contralateral limbs. # indicates HLU injured limbs differed from GC injured limbs. ^ indicates injured limbs differ by injury type (p<0.0001).