Table 2.
Multivariable1 odds ratios (OR) and 95% confidence intervals (95% CI) for the association between menstrual cycle characteristics and polycystic ovary syndrome and ovarian cancer by histologic subtype
|
|
||||||
|---|---|---|---|---|---|---|
| Irregular Cycles | Menstrual cycle length > 35 days | Polycystic ovary syndrome | ||||
| Cases (n) | OR (95% CI) | Cases (n) | OR (95% CI) | Cases (n) | OR (95% CI) | |
| Borderline | ||||||
| Serous | 1424 | 1.34 (1.16-1.55) | 1252 | 1.18 (0.87-1.59) | 1298 | 1.28 (0.84-1.96) |
| Mucinous | 985 | 1.21 (1.02-1.43) | 898 | 0.63 (0.41-0.98) | 867 | 0.51 (0.24-1.10) |
| Invasive | ||||||
| Low grade serous | 881 | 1.00 (0.81-1.25) | 770 | 0.48 (0.25-0.92) | 310 | 1.07 (0.43-2.66) |
| High grade serous | 5216 | 0.86 (0.78-0.95) | 4357 | 0.62 (0.48-0.80) | 4588 | 0.88 (0.62-1.26) |
| Mucinous | 840 | 0.95 (0.78-1.16) | 763 | 0.38 (0.19-0.76) | 530 | 0.61 (0.22-1.66) |
| Endometrioid | 1749 | 0.84 (0.72-0.98) | 1648 | 0.75 (0.54-1.06) | 1374 | 1.03 (0.63-1.67) |
| Clear cell | 895 | 0.68 (0.55-0.84) | 810 | 0.70 (0.43-1.13) | 673 | 0.77 (0.34-1.78) |
| Pheterogeneity2 | <0.0001 | 0.006 | 0.32 | |||
| Pheterogeneity3 | 0.08 | 0.32 | 0.86 | |||
1
Adjusted for age (continuous), oral contraceptive use (never use, <2, 2-<5, 5-<10, or 10+ years), parity (0, 1, 2, 3, 4+), history of tubal ligation (yes, no), family history of ovarian or breast cancer (yes, no), BMI (<20, 20-<25, 25-<30, 30+), race/ethnicity (white, non-white), and study site (AUS, CON, DOV, HAW, HOP, MAL, NCO, NEC, NJO, POL, SON, TOR, UCI, and USC).
2
Determined using polytomous logistic regression comparing all subtypes.
3
Determined using polytomous logistic regression comparing only invasive subtypes.