Appendix Table 6.
ORs (95% CIs) of In-Hospital Mortality Following TBI Comparing Statin Doses Among Atorvastatin, Rosuvastatin, or Simvastatin Users Prior to TBI Among Beneficiaries That Died Within 24 Hours of Hospitalization.
| Unadjusted |
Adjusteda |
|||
|---|---|---|---|---|
| Use in Months Prior to
TBI |
Use in Months Prior to
TBI |
|||
| −1 | −2 | −1 | −2 | |
| Atorvastatin | ||||
| ≤10 mg | Reference | Reference | Reference | Reference |
| >10 mg to ≤20 mg | 1.01 (0.86, 1.19) | 1.00 (0.85, 1.17) | 1.05 (0.87, 1.26) | 1.01 (0.84, 1.22) |
| >20 mg to ≤40 mg | 1.11 (0.92, 1.34) | 1.07 (0.89, 1.29) | 1.05 (0.85, 1.30) | 0.97 (0.78, 1.20) |
| >40 mg | 1.12 (0.87, 1.45) | 1.05 (0.81, 1.36) | 1.06 (0.78, 1.43) | 0.93 (0.68, 1.25) |
| Rosuvastatin | ||||
| ≤5 mg | Reference | Reference | Reference | Reference |
| >5 mg to ≤10 mg | 0.99 (0.64, 1.53) | 0.96 (0.63, 1.46) | 0.90 (0.54, 1.51) | 0.99 (0.60, 1.64) |
| >10 mg to ≤20 mg | 1.07 (0.64, 1.77) | 1.08 (0.66, 1.76) | 0.67 (0.35, 1.27) | 0.76 (0.41, 1.42) |
| >20 mg | 1.25 (0.65, 2.41) | 1.29 (0.69, 2.41) | 1.06 (0.47, 2.40) | 1.16 (0.53, 2.50) |
| Simvastatin | ||||
| ≤10 mg | Reference | Reference | Reference | Reference |
| >10 mg to ≤20 mg | 0.83 (0.69, 1.01) | 0.86 (0.70, 1.05) | 0.79 (0.64, 0.99) | 0.80 (0.64, 1.00) |
| >20 mg to ≤40 mg | 0.79 (0.65, 0.96) | 0.83 (0.68, 1.02) | 0.72 (0.58, 0.91) | 0.74 (0.59, 0.93) |
| >40 mg | 0.78 (0.61, 1.01) | 0.84 (0.65, 1.09) | 0.72 (0.54, 0.96) | 0.76 (0.57, 1.02) |
Abbreviations: OR, odds ratio; CI, confidence interval; TBI, traumatic brain injury; CHF, congestive heart failure; AMI, acute myocardial infarction; IHD, ischemic heart disease; VHD, valvular heart disease; ADRD, Alzheimer’s disease and related dementias; SNF, skilled nursing facility; SRRi, independent survival risk ratio.
Adjusted for demographic characteristics (age, sex, race, income, region); medications (antiplatelets, anticoagulants, beta-blockers, other statins); cardiovascular disease (CHF, AMI, IHD, VHD, hyperlipidemia, hypertension, prior stroke); diabetes; Alzheimer’s disease and related dementia; count of CCW chronic conditions excluding cardiovascular conditions (hypertension, hyperlipidemia, ischemic heart disease, congestive heart failure, acute myocardial infarction, valvular heard disease) and diabetes and ADRD; SNF stay in month prior to TBI; injury severity (SRRi, length of hospital stay); provider and hospital characteristics per 100 000 population (physicians, hospitals, hospitals with trauma services, hospitals with neurological services, beds).