Table 2.
ORs (95% CIs) of In-Hospital Mortality Following TBI Comparing Statin Users and Nonusers.
| Unadjusted |
|||
|---|---|---|---|
| Current Use | Recent Use | Past Use | |
| Any statin use | 0.96 (0.92, 1.00) | 1.10 (0.97, 1.25) | 0.93 (0.78, 1.10) |
| Atorvastatin | 0.99 (0.93, 1.06) | 1.19 (1.00, 1.42) | 0.82 (0.65, 1.03) |
| Fluvastatin | 0.71 (0.49, 1.05) | 0.69 (0.25, 1.91) | 0.32 (0.04, 2.31) |
| Lovastatin | 1.02 (0.91, 1.15) | 1.39 (0.96, 2.01) | 1.36 (0.91, 2.03) |
| Pravastatin | 1.03 (0.91, 1.16) | 0.86 (0.54, 1.38) | 0.88 (0.52, 1.50) |
| Rosuvastatin | 0.88 (0.77, 1.02) | 0.60 (0.36, 1.00) | 0.88 (0.54, 1.42) |
| Simvastatin | 0.93 (0.88, 0.99) | 1.03 (0.86, 1.24) | 0.89 (0.71, 1.13) |
| Adjusteda |
|||
| Current Use | Recent Use | Past Use | |
| Any statin use | 0.87 (0.82, 0.92) | 0.98 (0.84, 1.13) | 0.83 (0.68, 1.01) |
| Atorvastatin | 0.88 (0.82, 0.96) | 1.14 (0.94, 1.39) | 0.79 (0.61, 1.02) |
| Fluvastatin | 0.72 (0.47, 1.11) | 1.02 (0.36, 2.83) | 0.39 (0.05, 2.86) |
| Lovastatin | 0.97 (0.85, 1.12) | 1.09 (0.69, 1.72) | 1.24 (0.78, 1.95) |
| Pravastatin | 0.94 (0.81, 1.08) | 0.76 (0.44, 1.32) | 0.61 (0.31, 1.20) |
| Rosuvastatin | 0.79 (0.67, 0.94) | 0.68 (0.39, 1.18) | 0.90 (0.52, 1.55) |
| Simvastatin | 0.84 (0.79, 0.91) | 0.90 (0.73, 1.10) | 0.80 (0.61, 1.04) |
Abbreviations: OR, odds ratio; CI, confidence interval; TBI, traumatic brain injury; CHF, congestive heart failure; AMI, acute myocardial infarction; IHD, ischemic heart disease; VHD, valvular heart disease; ADRD, Alzheimer’s disease and related dementias; SNF, skilled nursing facility; SRRi, independent survival risk ratio.
Adjusted for demographic characteristics (age, sex, race, income, region); medications (antiplatelets, anticoagulants, beta-blockers, other statins); cardiovascular disease (CHF, AMI, IHD, VHD, hyperlipidemia, hypertension, prior stroke); diabetes; Alzheimer’s disease and related dementia; count of CCW chronic conditions excluding cardiovascular conditions (hypertension, hyperlipidemia, ischemic heart disease, congestive heart failure, acute myocardial infarction, valvular heard disease) and diabetes and ADRD; SNF stay in month prior to TBI; injury severity (SRRi, length of hospital stay); provider and hospital characteristics per 100 000 population (physicians, hospitals, hospitals with trauma services, hospitals with neurological services, beds).