Appendix Table 3.
ORs (95% CIs) of In-Hospital Mortality Following TBI Comparing Statin Doses Among Atorvastatin, Rosuvastatin, or Simvastatin Users Prior to TBI.
| Unadjusted |
Adjusteda |
|||
|---|---|---|---|---|
| Use in Months Prior to
TBI |
Use in Months Prior to
TBI |
|||
| −1 | −2 | −1 | −2 | |
| Atorvastatin | ||||
| ≤10 mg | Reference | Reference | Reference | Reference |
| >10 mg to ≤20 mg | 1.01 (0.87, 1.18) | 0.98 (0.84, 1.15) | 1.05 (0.88, 1.25) | 1.01 (0.85, 1.20) |
| >20 mg to ≤40 mg | 1.08 (0.90, 1.28) | 1.05 (0.88, 1.25) | 1.03 (0.83, 1.26) | 0.95 (0.78, 1.17) |
| >40 mg | 1.13 (0.89, 1.44) | 1.04 (0.81, 1.33) | 1.03 (0.77, 1.37) | 0.89 (0.66, 1.19) |
| Rosuvastatin | ||||
| ≤5 mg | Reference | Reference | Reference | Reference |
| >5 mg to ≤10 mg | 0.93 (0.63, 1.39) | 0.89 (0.60, 1.30) | 0.91 (0.56, 1.47) | 0.90 (0.57, 1.44) |
| >10 mg to ≤20 mg | 1.03 (0.65, 1.64) | 1.01 (0.65, 1.58) | 0.62 (0.34, 1.14) | 0.65 (0.36, 1.16) |
| >20 mg | 1.02 (0.54, 1.94) | 1.04 (0.57, 1.91) | 0.89 (0.40, 1.98) | 0.90 (0.42, 1.90) |
| Simvastatin | ||||
| ≤10 mg | Reference | Reference | Reference | Reference |
| >10 mg to ≤20 mg | 0.83 (0.69, 0.99) | 0.85 (0.70, 1.02) | 0.78 (0.63, 0.96) | 0.79 (0.63, 0.97) |
| >20 mg to ≤40 mg | 0.80 (0.66, 0.96) | 0.84 (0.69, 1.01) | 0.72 (0.58, 0.89) | 0.73 (0.59, 0.91) |
| >40 mg | 0.74 (0.58, 0.94) | 0.81 (0.64, 1.04) | 0.66 (0.50, 0.88) | 0.71 (0.54, 0.94) |
Abbreviations: OR, odds ratio; CI, confidence interval; TBI, traumatic brain injury; CHF, congestive heart failure; AMI, acute myocardial infarction; IHD, ischemic heart disease; VHD, valvular heart disease; ADRD, Alzheimer’s disease and related dementias; SNF, skilled nursing facility; SRRi, independent survival risk ratio.
Adjusted for demographic characteristics (age, sex, race, income, region); medications (antiplatelets, anticoagulants, beta-blockers, other statins); cardiovascular disease (CHF, AMI, IHD, VHD, hyperlipidemia, hypertension, prior stroke); diabetes; Alzheimer’s disease and related dementia; count of CCW chronic conditions excluding cardiovascular conditions (hypertension, hyperlipidemia, ischemic heart disease, congestive heart failure, acute myocardial infarction, valvular heard disease) and diabetes and ADRD; SNF stay in month prior to TBI; injury severity (SRRi, length of hospital stay); provider and hospital characteristics per 100 000 population (physicians, hospitals, hospitals with trauma services, hospitals with neurological services, beds).