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. Author manuscript; available in PMC: 2018 Mar 30.
Published in final edited form as: Wiley Interdiscip Rev Dev Biol. 2016 Sep 1;6(1):10.1002/wdev.245. doi: 10.1002/wdev.245

FIGURE 3.

FIGURE 3

Distinct modes of interzone formation. The joint interzone develops in the position of the presumptive joint and precedes articular cartilage differentiation and joint cavitation. The interzone can be generated from a single mesenchymal condensation (a, green) or through appositional growth of adjacent condensations (b). While cells outside the interzone undergo further cartilage differentiation (blue) and eventually hypertrophy and mineralize during endochondral bone development (red), cells within the interzone are maintained as immature chondrocytes at the articular surface (green flattened cells) and contribute to joint specializations such as the synovial membrane (orange). Also shown are chondrocyte progenitors within the perichondrium (blue flattened cells) and osteoblast progenitors within the periosteum (red flattened cells).