Table S2.

(A) Prediction of all-cause mortality – multivariate analysis containing PaCO₂ (kPa) – categories (<5; 5–7 – reference; >7). (B) Prediction of all-cause mortality – multivariate analysis containing desaturation. (C) Prediction of mortality by parameters of blood gases – ideal cutoff values. (D) Prediction of mortality – multivariate analysis containing PaO₂ (kPa) ≤7.1.

Prognostic parameter		Cox model of proportional risk
		HR (95% CI)			p-value
A
TLCO (%)*		0.979 (0.961–0.998)			0.032
6-MWD (m)*		0.996 (0.993–0.998)			0.001
PaCO2 (kPa)		–			–
B
BODE*		1.310 (1.168–1.470)			<0.001
TLC (%)*		0.985 (0.975–0.995)			0.004
Desaturation		–			–
	AUC (95% CI)	p-value	Cutoff	Sensitivity	Specificity
C
PaO2 (kPa)	0.590 (0.507; 0.673)	0.020	≤7.1	0.313	0.914
PaCO2 (kPa)	0.600 (0.521; 0.679)	0.010	≥0.54	0.537	0.654
Basal SpO2 (%)	0.607 (0.537; 0.676)	0.002	≤95.5	0.701	0.473
Minimal SpO2 during 6-MWT (%)	0.631 (0.569; 0.693)	<0.001	≤93.5	0.851	0.366
Greatest decrease in SpO2 (%)	0.610 (0.548; 0.671)	0.001	≥4.5	0.552	0.626
		Cox model of proportional risk
		HR (95% CI)			p-value
D
BMI*	0.921 (0.865–0.982)			0.012
RV (%)*		0.993 (0.987–1.000)			0.038
6-MWD*		0.994 (0.991–0.998)			<0.001
PaO2 (kPa) ≤7.1		5.135 (2.415–10.917)			<0.001

Notes:

^*HR represents change of risk of mortality, if parameter increases by unit. Desaturation, greatest decrease of SpO₂ during 6-MWT (%) >4% and/or minimal SpO₂ during (after) 6-MWT (%)<90%. Bold p-values represent statistically significant differences in mortality between tested end-points.

Abbreviations: AUC, area under curve; 6-MWT, 6-minute walking test; BMI, body mass index; BODE, body-mass index, airflow obstruction, dyspnea, and exercise; HR, hazard ratio; TLC, total lung capacity; SpO₂, basal peripheral capillary oxygen saturation; PaO₂, partial pressure of oxygen in arterial blood; PaCO₂, partial pressure of arterial carbon dioxide; TL_CO, transfer factor for carbon monoxide; RV, residual volume.