Figure 1.

(A) isPLA of phosphorylated p38α in alveolar macrophages of lung tissue from COPD patients and controls. Data are representative of two experiments. (B) AZD7624 inhibition of LPS-stimulated pro-inflammatory cytokine TNF-α in human alveolar macrophages. Data are presented as mean ± SEM of n=4. AZD7624 attenuation of (C) sputum neutrophil % differential and (D) TNF-α changes from baseline compared with placebo in the human LPS challenge study. Data are presented as mean ± SEM of 24–27 subjects per treatment group. ^ap<0.001 vs placebo.

Abbreviations: isPLA, in situ proximity ligation assay; LPS, lipopolysaccharide; SEM, standard error of the mean; TNF-α, tumor necrosis factor-α.