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TGF/TGFR signaling axis. SMAD proteins play a central role in transducing the signals intracellularly. SIRT7 modulates SMAD4 degradation via β-transducin repeat-containing protein (β-TrCP1). SMAD4, β-TrCP1, and SIRT7 complex formation results in shutdown of the TGF pathway. SMAD: Sma Mothers Against Decapentaplegic; β-TrCP: β-transducin repeat-containing protein; CXCL8: chemokine CXC motif, ligand 8; TGF: transforming growth factor; ANGPTL4: angiopoietin-like 4.
