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An overview of resveratrol-mediated targeting of multiple signaling pathways. (A) TGF/SMAD signaling pathway regulation by resveratrol; (B) WNT/Catenin pathway regulation by resveratrol; (C) Resveratrol increases negative regulators of STAT signaling (SHP-2, PIAS, and PTP) and inhibits JAK-mediated STAT phosphorylation. STAT3 transcriptionally upregulates miR-21, and targets the tumor suppressor gene PCAT29.
