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. 2018 Feb 27;19(3):660. doi: 10.3390/ijms19030660

Figure 1.

Figure 1

Systolic blood pressure (BP) following ET receptor type A (ETA) blockade by BQ610 in normotensive and deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Systolic BP was measured by tail-cuff plethysmography as described in Materials and Methods and expressed in mmHg ± SEM. (a) Basal systolic BP. Basal values were registered 48 h before BQ610 administration. *** p < 0.001 vs. control. (b) Time course of systolic BP. Systolic BP was registered following BQ610 administration at 24, 48, 72, 96, 120, and 144 h. * p < 0.05, ** p < 0.01, and *** p < 0.001 vs. the respective time control; ††† p < 0.001 vs. the respective time DOCA-salt. (c) Average systolic BP. Each bar represents the area under each curve (shown in b) between 0 and 144 h. *** p < 0.001 vs. control; ††† p < 0.001 vs. DOCA-salt; ‡‡‡ p < 0.001 vs. DOCA-salt + BQ610. Number of animals: control, 17; BQ610 (12 ng/h), 12; BQ610 (24 ng/h), 8; DOCA-salt, 17; DOCA-salt + BQ610 (12 ng/h), 11; and DOCA-salt + BQ610 (24 ng/h), 10.