Table 1.
Systolic blood pressure (BP) values following ET receptor type A (ETA) blockade. Systolic BP was expressed as mmHg ± SEM. C, normotensive control; DOCA, DOCA-salt hypertensive rats.
| Experimental Groups | Systolic BP Following ETA Blockade by BQ610 | ||||
|---|---|---|---|---|---|
| 24 h | 48 h | 72 h | 120 h | 144 h | |
| Control | 114.1 ± 2.3 | 113.0 ± 2.2 | 113.7 ± 2.7 | 114.4 ± 2.3 | 115.8 ± 2.5 |
| C + BQ610 (12 ng/h) | 117.5 ± 2.4 NS | 117.9 ± 3.0 NS | 116.6 ± 2.3 NS | 119.8 ± 2.7 NS | 115.1 ± 3.9 NS |
| C + BQ610 (24 ng/h) | 117.2 ± 1.9 NS | 118.8 ± 1.5 NS | 120.7 ± 3.2 NS | 120.1 ± 1.9 NS | 118.3 ± 3.3 NS |
| DOCA-salt | 164.1 ± 2.6 *** | 168.5 ± 3.7 *** | 170.1 ± 4.1 *** | 168.7 ± 2.6 *** | 173.1 ± 4.2 *** |
| DOCA + BQ610 (12 ng/h) | 134.7 ± 3.3 ***,††† | 138.8 ± 5.8 ***,††† | 141.5 ± 4.5 ***,††† | 149.5 ± 3.0 ***,††† | 143.9 ± 5.6 ***,††† |
| DOCA + BQ610 (24 ng/h) | 124.1 ± 3.8 ††† | 125.2 ± 3.7 *,††† | 129.6 ± 3.2 **,††† | 130.8 ± 3.0 **,††† | 132.8 ± 3.7 ***,††† |
* p < 0.05, ** p < 0.01, and *** p < 0.001 vs. control; ††† p < 0.001 vs. DOCA-salt. Number of animals: control, 17; BQ610 (12 ng/h), 12; BQ610 (24 ng/h), 8; DOCA-salt, 17; DOCA-salt + BQ610 (12 ng/h), 11; and DOCA-salt + BQ610 (24 ng/h), 10. NS: Not significant.