Table 2.
Heart rate (HR) values following ETA blockade. HR is expressed as beats per minute (BPM) ± SEM. C, normotensive control; DOCA, DOCA-salt hypertensive rats. Number of animals: control, 17; BQ610 (12 ng/h), 12; BQ610 (24 ng/h), 8; DOCA-salt, 17; DOCA-salt + BQ610 (12 ng/h), 11; and DOCA-salt + BQ610 (24 ng/h), 10.
| Experimental Groups | HR During Long-Term ETA Antagonist Treatment | ||||
|---|---|---|---|---|---|
| 24 h | 48 h | 72 h | 120 h | 144 h | |
| Control | 367 ± 6 | 362 ± 6 | 358 ± 6 | 363 ± 6 | 363 ± 6 |
| C + BQ610 (12 ng/h) | 364 ± 5 | 361 ± 5 | 367 ± 9 | 355 ± 10 | 348 ± 7 |
| C + BQ610 (24 ng/h) | 357 ± 7 | 356 ± 8 | 345 ± 3 | 364 ± 5 | 358 ± 5 |
| DOCA-salt | 347 ± 7 | 359 ± 9 | 349 ± 11 | 366 ± 9 | 356 ± 8 |
| DOCA + BQ610 (12 ng/h) | 356 ± 6 | 365 ± 9 | 348 ± 8 | 360 ± 7 | 349 ± 8 |
| DOCA + BQ610 (24 ng/h) | 359 ± 11 | 364 ± 8 | 351 ± 7 | 371 ± 9 | 359 ± 10 |