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. 2018 Feb 27;19(3):663. doi: 10.3390/ijms19030663

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Blood-derived neuronal exosomes contain several different forms of tau. (A) Our in-house BT2-Tau5 ELISA detected tau in all plasma neuron-derived exosomes studied. On the day of testing the LLoQ for the assay was 7.81 pg/mL. (B) Full-length tau was detected with an in-house Simoa-based assay which on the day of testing had an LLoQ of 0.74 pg/mL. (C) The concentration of ptau-181 was measured with the Innotest commercial kit, which, on the day of testing, had an LLoQ of 24.5 pg/mL. For each assay, the LLoQ is indicated with a red line.