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Bacterial enzymes as therapeutics for IgG dependent diseases. Streptococcus pyogenes secreted IdeS (A) cleaves IgG molecules at the hinge region and EndoS (B) cleaves N-linked carbohydrates specifically present on Fc region. Arthritis is ameliorated either after IgG-degrading enzyme (IdeS) or Endo-β-N-acetylglucosaminidase (EndoS) cleavage of pathogenic IgG (C). HE stained joint morphology of mouse with and without arthritis after treatment. Magnification, 10×.
