Table 1.
Inhibitory activities (as EC50) of thiazolyl resorcinols inhibitors with modified rings. (a) Influence of modifications of the resorcinol ring; and (b) effects of replacement or modification of the aminothiazole moiety. The EC50 for kojic acid (W056) is shown for comparison.
| (a) | (b) | ||||
|---|---|---|---|---|---|
| Code | Structure | EC50 (µM) | Code | Structure | EC50 (µM) |
| W311 |  |
3.2 ± 0.1 | W547 |  |
3.2 ± 0.6 |
| W452 |  |
19 ± 1 | W633 |  |
750 ± 60 |
| W539 |  |
>3000 | W548 |  |
4.6 ± 0.2 |
| W568 |  |
>3000 | W632 |  |
>3000 |
| W480 |  |
>3000 | W607 |  |
56 ± 3 |
| W624 |  |
>3000 | W701 |  |
>3000 |
| W056 |  |
520 ± 50 | |||