Figure A2.

GJA1 mRNA level in breast cancer clinical samples is higher in ER-positive tumors in four datasets. (a) GJA1 mRNA level in breast tumors stratified by estrogen receptor status determined as described in Material and Methods. p value: * <0.05; ** <0.01; *** <0.001. (b) Expression of GJA1 vs. estrogen receptor alpha (ESR1) mRNA in each subtype and in normal breast tissue. (c) Bootstrapped correlations between ESR1 and GJA1 mRNA level either in pooled breast cancer tumors or in individual intrinsic subtypes and in normal breast tissue. Data from Vanvliet, NKI, Curtis Discovery and Curtis Validation datasets.