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. 2018 Mar 5;19(3):738. doi: 10.3390/ijms19030738

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Wnt signaling pathway (mmu04310) maps and Signaling pathways regulating pluripotency of stem cells (mmu04550) derived from DAVID analysis. Green boxes and arrows indicate the genes and interactions in the pathway. +p and −p denote phosphorylation and dephosphorylation, respectively. The genes with red stars are those that were upregulated with nicotine treatment and downregulated with mecamylamine. Additionally, the genes with blue stars represent those that were upregulated in response to nicotine and not downregulated with mecamylamine treatment. The sub-pathways related to the canonical and non-canonical Wnt pathways are highlighted with a blue box.