Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model depicting the proposed role of nAChR signaling in intestinal stem cell function. Non-neuronal ACh activates the nicotinic receptor α2/β4 localized in the Paneth cells to modulate the expression levels of Wnt5a and/or Wnt9b. The Wnts then mediate Wnt pathway activity through various frizzled receptors. Eventually, proliferation and differentiation of stem cells are enhanced.
