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. 2018 Mar 7;19(3):752. doi: 10.3390/ijms19030752

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Anti-BTLA antibodies induce cytotoxic lymphocyte marker expression. PyMT tumors were treated with 5 mg/kg of each anti-BTLA, anti-PD-1 or isotype control (IgG2A) antibodies (n = 7 each) twice weekly for three weeks once the first tumor reached a size of 0.5 cm in diameter. Tumors were harvested for quantitative PCR analysis 21 days after initial treatment. The expression of the indicated genes relative to the house-keeping gene Rps27a is displayed. p-values were calculated using one-way ANOVA with Bonferroni’s correction, * p < 0.05.