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Interplay between the regulation of bioenergy and the molecular clock. Activated AMPK directly or indirectly phosphorylates core circadian repressors (i.e., PER/CRY). DEC, another circadian repressor, suppresses the transcription of Lkb1 which codes for a serine-threonine kinase that directly phosphorylates and activates AMPK, thus forming a reciprocal relationship between regulators of bioenergy and the circadian clock.
