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. 2018 Mar 9;19(3):786. doi: 10.3390/ijms19030786

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Multiple sequence alignment of MS associated retrovirus MSRV and predicted ORFs from chromosomes 12 and 18. The two megabase pairs flanking rs9807334 on chromosome 18 were analyzed using getorf for the presence of open reading frames (ORFs) with a minimal length of one kilobase. Sixteen ORFs were identified (see Supplementary Table S1). These ORFs were analyzed using BLASTP against the database of retro-transcribing viruses (taxid:35268). One ORF with high sequence similarity to retroviruses was identified. Presented is an alignment of this ORF (ORF14) and a polyprotein sequence from the multiple sclerosis associated retrovirus (MSRV; accession number AAB66528.1:6-379) and a similar sequence from chromosome 12 (Chr.12; accession number EAW96383.1).