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. 2018 Mar 9;19(3):786. doi: 10.3390/ijms19030786

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic organization of the immunoglobulin locus including rs11621145 on human chromosome 14. The two megabase pairs flanking rs11621145 were analyzed using getorf for the presence of open reading frames (ORFs) with a minimal length of one kilobase. One hundred and sixty-nine ORFs were identified (see Supplementary Table S3). These ORFs were analyzed using BLASTP against the database of retro-transcribing viruses (taxid:35268). Nine ORFs with sequence similarity to retroviruses were identified. A cluster of three ORFs forming a retrovirus-like composite element is located between the HOMER homolog 2 pseudogene 2 and the solute carrier family 20 member 1 pseudogene 2 in the immunoglobulin heavy chain (IGH) locus. For a complete list of all genes in this chromosomal region, see Supplementary Table S4. Arrows indicate the direction of the ORFs.