Table 4.
Top affected pathways and upstream regulators. TGFβ1: Transforming growth factor beta 1, TNF: tumor necrosis factor, IFNG: Interferon gamma.
| Pathways | p-Value | Overlap |
| Th2 pathway | 6.23 × 10−11 | 17.3% 26/150 |
| Th1 and Th2 activation pathway | 3.10 × 10−10 | 15.1% 28/185 |
| Th1 pathway | 3.12 × 10−8 | 15.6% 21/135 |
| Antigen presentation pathway | 9.02 × 10−8 | 28.9% 11/38 |
| Hepatic fibrosis/hepatic stellate cell activation | 3.88 × 10−7 | 12.6% 23/183 |
| Upstream Regulators | p-Value | |
| IFNG | 3.41 × 10−20 | |
| TNF | 7.26 × 10−16 | |
| Lipopolysaccharide TGG | 2.01 × 10−15 | |
| TGFβ1 | 1.03 × 10−14 | |
| Beta-estradiol | 1.12 × 10−14 |