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Action potential-dependent ATP release from type II taste bud cells through voltage-gated CALHM1 channels mediates fast purinergic neurotransmission of sweet, bitter, and umami tastes. Δψ, receptor potential; ER, endoplasmic reticulum; DAG, diacylglycerol; InsP3, inositol 1,4,5-trisphosphate; PLCβ2, phospholipase β2.
