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. 2018 Mar 13;19(3):829. doi: 10.3390/ijms19030829

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Fraxinellone inhibits B cell maturation. (A,B) CD19⁺ B cells were activated by lipopolysaccharide. After treatment with or without fraxinellone (40 μM), the relative expression levels of AID and Blimp-1 in CD19⁺ B cells were determined with RT-PCR. (C) The level of immunoglobulin G in the culture supernatant was measured using ELISA in the presence of fraxinellone at doses of 0–40 μM. In all culture conditions, CD19⁺ B cells were stimulated by lipopolysaccharide. Data represent the mean of three independent experiments ± SEM. Nil, no stimulation; LPS, stimulation with lipopolysaccharide; Frx, fraxinellone; AID, activation-induced cytidine deaminase; Blimp-1, B lymphocyte-induced maturation protein-1; IgG, immunoglobulin G; * p < 0.05; ** p < 0.01; *** p < 0.001.