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. 2018 Mar 13;19(3):841. doi: 10.3390/ijms19030841

Table 1.

Summary of synergic or antagonist cocktail effects of BaP and PCBs on genes expression in “Time 1” and “Time 2”: : down-regulation with BaP and down-regulation with PCBs. : up-regulation with BaP and up-regulation with PCBs. : down-regulation with BaP and up-regulation with PCBs. : up-regulation with BaP and down-regulation with PCB. Inflammatory genes are in bold characters. Adipokines are in italic and bold characters. The level of significance of differences between BaP-treated and PCB-treated assays is * p < 0.05; ** p < 0.01; *** p < 0.001. For details see the tables of significances (Table A1 in Appendix A).

Treatment and Time Synergism of BaP and PCB Antagonism of BaP and PCB
↓↓ ↑↑ ↓↑ ↑↓
BaP and PCB118 Time 1 PPARγ **
Glut-4 ***
Lipin-1a *
Lipin-1b **
ATGL **
FABP-4 **
FAS **
HSL ***
SREBP *
CXCL-10 **
Adiponectin ***
Leptin ****
CYP1A1 **
Glut-1 **
BaP and PCB118 Time 2 PPARγ *
Glut-4 **
Lipin-1a *
Lipin-1b *
HSL *
PAI-1 **
CYP1A1 * Leptin ** Adiponectin **
BaP and PCB153 Time 1 PPARγ ***
Glut-4 ***
Lipin-1a **
Lipin-1b ***
ATGL ***
FABP-4 ****
FAS ***
HSL **
CXCL-10 **
Adiponectin ***
CYP1A1 **
TNFα ***
IL6 **
Glut-1 ***
MCP-1 ***
BaP and PCB153 Time 2 Glut-1 *
Glut-4 **
Lipin-1a *
Lipin-1b *
FAS *
HSL *
PAI-1 **
Leptin ** MCP-1 **
CXCL-10 **
Adiponectin **