Table 1.
Treatment and Time | Synergism of BaP and PCB | Antagonism of BaP and PCB | |||
---|---|---|---|---|---|
↓↓ | ↑↑ | ↓↑ | ↑↓ | ||
BaP and PCB118 | Time 1 | PPARγ ** Glut-4 *** Lipin-1a * Lipin-1b ** ATGL ** FABP-4 ** FAS ** HSL *** SREBP * CXCL-10 ** Adiponectin *** Leptin **** |
CYP1A1 ** Glut-1 ** |
||
BaP and PCB118 | Time 2 | PPARγ * Glut-4 ** Lipin-1a * Lipin-1b * HSL * PAI-1 ** |
CYP1A1 * | Leptin ** | Adiponectin ** |
BaP and PCB153 | Time 1 | PPARγ *** Glut-4 *** Lipin-1a ** Lipin-1b *** ATGL *** FABP-4 **** FAS *** HSL ** CXCL-10 ** Adiponectin *** |
CYP1A1 ** TNFα *** IL6 ** |
Glut-1 *** MCP-1 *** |
|
BaP and PCB153 | Time 2 | Glut-1 * Glut-4 ** Lipin-1a * Lipin-1b * FAS * HSL * PAI-1 ** |
Leptin ** |
MCP-1 ** CXCL-10 ** Adiponectin ** |