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. 2018 Mar 16;19(3):888. doi: 10.3390/ijms19030888

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Preventive effects of low doses of hOCIF on tumor cell proliferation, osteolysis and cytokine levels in the tumor microenvironment. (A) We set 3.0 mg/kg body weight as the full dose, and examined the preventive effects of hOCIF at one-half and one-fifth dose of the full dose; (B) Pretreatment with hOCIF suppressed tumor volume in a dose dependent manner; (C) hOCIF treatment significantly suppressed cell proliferation at the TB-interface in a dose dependent manner (p < 0.001); (D) The bone destruction index was suppressed by pretreatment with hOCIF in a dose dependent manner; (E) mOPG levels at the TB-interface was increased in a dose dependent manner. *, **, *** p < 0.05, p < 0.01, p < 0.001.