Table 1.
Genetic variants (SNPs) associated to NAFLD progression.
| Gene | Function | Phenotype | Variant |
|---|---|---|---|
| PNPLA3 | Lipid droplets | ↑ NAFLD, NASH, fibrosis, HCC | rs738409 C>G |
| MBOAT7 | Phospholipid metabolism | ↑ NAFLD-HCC risk | rs641738 C>T |
| APOB | VLDL secretion | ↑ NAFLD, NASH, fibrosis, HCC | Several |
| TM6SF2 | VLDL secretion | ↑ NAFLD, NASH, fibrosis | rs58542926 C>T |
| GCKR | De novo lipogenesis regulation | ↑ NAFLD, NASH, fibrosis | rs780094 A>G |
| KLF6 | De novo lipogenesis regulation; fibrogenesis | ↓ fibrosis | rs3750861 G>A |
| IL28B | Innate immunity, alternative IFNL3/4 transcription | ↓ fibrosis | rs12979860 C>T |
| SOD2 | Mitochondrial antioxidant | ↑ fibrosis | rs4880 C>T |
APOB, Apolipoprotein B; KLF6, Krueppel-like factor 6; IL28B, interleukin 28B; SOD2, Superoxide dismutase 2; VLDL: very low-density lipoproteins. ↑—increased, ↓—decreased.