Figure 8.

The dynamic network corresponding to the six mutation sites in IL-2 was detected by cross-correlation analysis and COREX/BEST algorithm. (a) The motion correlated regions relative to the mutation sites derived from MD simulation are shown in magenta on the cartoon representation of IL-2 structure; (b) A combined energetic coupling region based on COREX/BEST algorithm are shown in red on the cartoon representation of IL-2 structure; (c) Comparisons of the dynamic networks calculated by cross-correlation analysis and COREX/BEST algorithm, and with the regions undergoing structural changes in the protein crystals. Along the protein sequence, blue regions indicate the residues within the dynamic networks. Boxes with diagonal bars were painted upon the blue regions to indicate overlapped regions of the dynamic networks calculated by these two methods. Boxes with vertical bars indicate the structural change regions from experimental data (Crystal Strucrues). Numbers along the sequence show residues index.