Table 1.
The percentage (mean ± SEM) of neurons showing the presence of the chosen neuronal active substances.
| Part of ENS | Animal Group | Active Neuronal Substances Studied During the Experiment | ||||
|---|---|---|---|---|---|---|
| VAChT | VIP | SP | GAL | CART | ||
| Myenteric plexus | C group | 18.35 ± 0.21 | 15.05 ± 0.17 | 11.01 ± 0.16 | 7.91 ± 0.04 | 7.58 ± 0.39 |
| LD group | 17.54 ± 0.24 * | 15.21 ± 0.35 | 11.03 ± 0.47 | 8.06 ± 0.32 | 10.70 ± 0.40 *** | |
| HD group | 13,67 ± 0.18 *** | 17.51 ± 0.04 *** | 15.15 ± 0.28 *** | 13.40 ± 0.39 *** | 17.09 ± 0.52 *** | |
| Outer submucous plexus | C group | 19.93 ± 0.10 | 10.57 ± 0.39 | 9.76 ± 0.12 | 9.60 ± 0.41 | 4.47 ± 0.11 |
| LD group | 18.24 ± 0.23 *** | 12.61 ± 0.11 *** | 10.39 ± 0.32 | 12.92 ± 0.42 *** | 5.29 ± 0.36 | |
| HD group | 14.70 ± 0.12 *** | 16.00 ± 0.08 *** | 17.73 ± 0.33 *** | 18.08 ± 0.35 *** | 9.65 ± 0.20 *** | |
| Inner submucous plexus | C group | 26.42 ± 0.38 | 7.64 ± 0.17 | 9.32 ± 0.37 | 14.14 ± 0.13 | 3.80 ± 0.16 |
| LD group | 25.21 ± 0.23 * | 10.85 ± 0.34 *** | 10.32 ± 0.31 | 18.17 ± 0.08 *** | 5.30 ± 0.24 *** | |
| HD group | 20.70 ± 0.11 *** | 17.80 ± 0.28 *** | 15.83 ± 0.42 *** | 22.72 ± 0.30 *** | 8.02 ± 0.04 *** | |
Vesicular acetylcholine transporter (VAChT), vasoactive intestinal polypeptide (VIP), substance P (SP), galanin (GAL), or cocaine- and amphetamine-regulated transcript peptide (CART) in relation to protein gene product 9.5 (PGP 9.5)-positive neurons stained for PGP 9.5 in the control (C) group and after administration of low (LD group) and high (HD) doses of bisphenol A (BPA). Statistically significant (p ≤ 0.05) and highly statistically significant (p ≤ 0.001) differences between the C group and LD group, as well as the C group and HD group, are marked with * and ***.