PDMS-SiO2 bilayer substrates produce reconfigurable programmable topography. PDMS-SiO2 bilayer substrates are pre-strained to εpre = 9% and coated with SiO2 layers of hf = 100 nm. a) Wavelengths and amplitudes of the surface features are measured as a function of Δε = εapp – εre. Values of Δε < 0%, Δε = 0% and Δε > 0% generate perpendicular wavy gratings (W⊥), featureless flat substrates (F), and parallel wavy gratings (W||)features, respectively. b) Fast Fourier Transforms (FFT) of PDMS-SiO2 bilayer substrates with the for −9% < Δε < +9%. The intensity and relative orientation of FFT signals confirm the presence (absence) of distinguishable features and the orientation of wavy grating arrays in the following discrete states: W⊥, F, and W||.