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Model for the dual role of TorC in E. coli. Immature TorC cytochrome inhibits (− arrow) TorS kinase activity from the periplasm by binding to the detector region of TorS. This interaction depends on the C-terminal domain of apoTorC. After heme insertion, holoTorC no longer binds to TorS, and the N-terminal domain of TorC then strongly interacts with TorA, allowing formation of a functional TorC–TorA respiratory complex.
