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. 2018 Feb 20;115(10):E2376–E2385. doi: 10.1073/pnas.1716973115

Fig. 2.

Fig. 2.

Constitutive expression of ivr genes reduces in vivo colonization fitness. Results are presented as the competitive index (CI) representing the output ratio of strains constitutively expressing the gene(s) of interest from a pBR322c derivative versus a fully virulent LacZ− derivative of the WT harboring the empty vector in LB broth (in vitro) and in vivo using the infant mouse model. The following competitions are shown: (A) WT pVC0072 vs. ∆lacZ p; (B) WT pVC0227 vs. ∆lacZ p; (C) WT pVC0704-2 vs. ∆lacZ p; (D) WT pVC0784 vs. ∆lacZ p; (E) WT pVC0998 vs. ∆lacZ p; (F) WT pVC1033 vs. ∆lacZ p; (G) WT pVC2137 vs. ∆lacZ p; (H) WT pclcA vs. ∆lacZ p; (I) WT pVCA0576 vs. ∆lacZ p. Each circle represents the CI from a single assay. Horizontal bars indicate the median of each dataset. The asterisks indicate significantly different medians of the in vivo compared with the respective in vitro dataset (n ≥ 6, P < 0.05, using a Mann–Whitney U test).