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Conserved G-protein residues and selectivity determinants. (A) Residues across G-protein subtypes that are involved in G-protein selectivity. Side chains are colored orange on the rhodopsin–Gi complex model. The residue numbers for Gαi are indicated. (B) Conserved residues across G-protein subtypes involved in stabilizing the receptor-bound state. Side chains are indicated in dark blue on the rhodopsin–Gi complex model.
