Fig. 7.

Rearing mice in a 2-h light/23.5-h dark lighting cycle does not reverse the reduced body mass and body length of Discordant mice. Discordant mice (Vgat-Cre⁺ CK1δ^fl/fl ε^fl/+, red) and Cre-negative littermates (No-Cre CK1δ^fl/fl ε^fl/+, blue) were housed in a 25.5-h T-cycle throughout their life. (A) Weekly body mass measurements between 5 and 20 wk of age show that Discordant mice maintained a lower body mass. (B) Body length (distance from nose to base of tail) was significantly shorter in Discordant mice. (C) Glucose tolerance tests performed in the middle of the rest phase revealed that glucose tolerance of Discordant mice was not worse than that of Cre-negative control mice. Values represent the sex-corrected average of males and females. Data are represented as mean ± SEM. Sample size per genotype is indicated at the base of each bar. Asterisks indicate significant differences between genotypes at the indicated time point. AUC, area under curve.