Fig. 1.

PMIDs, NIH-funded PMIDs, NIH funding year, and costs associated with 210 NMEs approved from 2010–2016 or the 151 known molecular targets for these NMEs. (A) PMIDs identified searching for NMEs (drug search) or their molecular targets (target search). (B) PMIDs associated with NIH funding in RePORTER (1980–present). (C) Funding years associated with NIH-funded PMIDs directly related to NMEs (drug) or their targets (target only). (D) Project costs (2000–2016) associated with funding years (all), costs directly related to the NMEs (drug), or costs related to the molecular target only (target only). Open circles indicate years of supplemental funding from the ARRA. Dashed line shows trend without ARRA data. Shaded areas show the years of drug approvals.