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. Author manuscript; available in PMC: 2018 Mar 30.
Published in final edited form as: J Control Release. 2015 Sep 30;218:29–35. doi: 10.1016/j.jconrel.2015.09.061

Fig. 4.

Fig. 4

RGD-M/sPMI micelle activates main p53 cellular functions in U87MG cells. (A) The RGD-M/sPMI micelle arrests cell-cycle progression in U87MG cells. Exponentially growing U87MG cells were incubated with 10 µM of the RGD-M/sPMI micelle for 24 h, and cell cycle distribution was determined by PI labeling and cell-cycle analysis. Numbers indicate the percentage of S-phase cells. (B) Apoptotic response to 10 µM of Nutlin-3, sPMI, RGD-M/sPMI and RGD-M micelle in U87MG cells for 24 h, and the percentage of apoptotic cells (mean ± SEM) were determined by the Annexin V assay.