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. Author manuscript; available in PMC: 2019 Apr 10.
Published in final edited form as: J Control Release. 2018 Feb 10;275:229–241. doi: 10.1016/j.jconrel.2018.02.003

Figure 1. Plasma concentration-time profiles of lopinavir (LPV; panel A), ritonavir (RTV; panel B), and tenofovir (TFV; panel C) in macaques following a single SC dose of the triple-drug combination in either the soluble (“free”; red open circles [O] and dotted line) or TLC-ART101 (blue closed circles [•] and solid line) formulation.

Figure 1

The top graphs in panels A, B, and C are plasma concentration-time profiles of the first 24 hr after SC dosing, and the bottom graphs are the entire time course over 336 hr (2 weeks). Please note the differences in the y-axis scales for the top graphs over 24 hr to highlight relevant plasma concentrations for each ARV. Plasma limit of quantification (LOQ)/limit of detection (LOD) = lopinavir: 10/5, ritonavir: 50/25, tenofovir: 250/100 pg/mL. Ritonavir (intended as a PK booster for lopinavir) in plasma after TLC-ART101 dosing was <LOQ in N=2 at 192 and 336 hr. Geometric mean ± SD (N=3-8).