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. 2018 Mar 27;32(2):139–152. doi: 10.1007/s40259-018-0273-6

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Two-dimensional plots of the overall reduction in the number of RVGE hospitalizations (a, b) and deaths (c, d) over 3 (a, c) and 5 years (b, d) risk windows (x axis) and the increase in numbers of IS hospitalizations (a, b) and deaths (c, d) post vaccination over two 7-day risk windows (y axis) for cohorts of 10⁵ (hospitalization) and 10⁶ (death) vaccinated French children. Each point represents the joint calculations of benefits and risks under a specific scenario selected at random from each of the random distributions of the input parameters. The results presenting the highest frequencies across the 10⁶ simulations are colored in red. The plots illustrate the dominance of the hospitalization and death benefits in comparison to the hospitalization and death risks under all scenarios. D1 dose 1, D2 dose 2, hosp. hospitalization, IS intussusception, RVGE rotavirus gastroenteritis, sub. subjects

Fig. 2 — Two-dimensional plots of the overall reduction in the number of RVGE hospitalizations (a, b) and deaths (c, d) over 3 (a, c) and 5 years (b, d) risk windows (x axis) and the increase in numbers of IS hospitalizations (a, b) and deaths (c, d) post vaccination over two 7-day risk windows (y axis) for cohorts of 10⁵ (hospitalization) and 10⁶ (death) vaccinated French children. Each point represents the joint calculations of benefits and risks under a specific scenario selected at random from each of the random distributions of the input parameters. The results presenting the highest frequencies across the 10⁶ simulations are colored in red. The plots illustrate the dominance of the hospitalization and death benefits in comparison to the hospitalization and death risks under all scenarios. D1 dose 1, D2 dose 2, hosp. hospitalization, IS intussusception, RVGE rotavirus gastroenteritis, sub. subjects