Table 2.
Benefit and risk of vaccination with Rotarix
| Event | Age group | Benefit: prevented RVGE | Risk: excess IS | BR ratio (prevented RVGE/excess IS) | BR difference (prevented RVGE − excess IS) | ||||
|---|---|---|---|---|---|---|---|---|---|
| Mean (SD) | Median (95% CI)c | Mean (SD) | Median (95% CI)c | Mean (SD) | Median (95% CI) | Mean (SD) | Median (95% CI) | ||
| Hosp.a | < 3 year | 1330 (167) | 1339 (978–1631) | 1.29 (1.17) | 0.87 (0.28–4.85) | 1754 (1514) | 1546 (226–4936) | 1329 (168) | 1338 (976–1630) |
| < 5 year | 1407 (211) | 1407 (991–1821) | 1854 (1609) | 1624 (240–5243) | 1406 (211) | 1406 (989–1820) | |||
| Deathb | < 3 year | 9.31 (3.27) | 8.92 (4.06–16.77) | 0.0188 (0.0193) | 0.0125 (0.0030–0.0754) | 973 (1106) | 707 (88–3472) | 9.29 (3.28) | 8.91 (4.04–16.75) |
| < 5 year | 9.90 (3.72) | 9.39 (4.14–18.55) | 1033 (1188) | 743 (93–3723) | 9.88 (3.72) | 9.37 (4.11–18.53) | |||
BR benefit–risk, CI credible interval, Hosp. hospitalization, IS intussusception, RVGE rotavirus gastroenteritis, SD standard deviation, y years
aVaccine-prevented RVGE-related and vaccine-caused IS-related hospitalizations per 105 vaccinated children followed from birth to 3 and 5 years of age, respectively; IS-related hospitalizations caused during 2 risk windows of 7 days post dose 1 and post dose 2 of Rotarix
bVaccine-prevented RVGE-related and vaccine-caused IS-related deaths per 106 vaccinated children followed from birth to 3 and 5 years of age, respectively; IS-related deaths caused during 2 risk windows of 7 days post dose 1 and post dose 2 of Rotarix
cThe limits of the 95% CIs were determined using the 2.5 and 97.5% percentiles of the empirical distributions